6jr0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6jr0 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of the human nucleosome phased with 12 selenium atoms==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6jr0]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JR0 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JR0 FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jr0 OCA], [http://pdbe.org/6jr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jr0 RCSB], [http://www.ebi.ac.uk/pdbsum/6jr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jr0 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Horikoshi, N]]

[[Category: Kagawa, W]]

[[Category: Kujirai, T]]

[[Category: Kurumizaka, H]]

[[Category: Saotome, M]]

[[Category: Urano, K]]

[[Category: Yuzurihara, H]]

[[Category: Chromatin]]

[[Category: Gene regulation]]

[[Category: Gene regulation-dna complex]]

[[Category: Histone]]

[[Category: Nucleosome]]

[[Category: Sad phasing]]

[[Category: Selenomethionine]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6jr0 is ON HOLD  until Paper Publication
+==Crystal structure of the human nucleosome phased with 12 selenium atoms==
+<StructureSection load='6jr0' size='340' side='right'caption='[[6jr0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6jr0]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JR0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jr0 OCA], [http://pdbe.org/6jr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jr0 RCSB], [http://www.ebi.ac.uk/pdbsum/6jr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jr0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>   Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Horikoshi, N]]
+[[Category: Kagawa, W]]
+[[Category: Kujirai, T]]
+[[Category: Kurumizaka, H]]
+[[Category: Saotome, M]]
+[[Category: Urano, K]]
+[[Category: Yuzurihara, H]]
+[[Category: Chromatin]]
+[[Category: Gene regulation]]
+[[Category: Gene regulation-dna complex]]
+[[Category: Histone]]
+[[Category: Nucleosome]]
+[[Category: Sad phasing]]
+[[Category: Selenomethionine]]