5n0l: Difference between revisions

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<StructureSection load='5n0l' size='340' side='right'caption='[[5n0l]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
<StructureSection load='5n0l' size='340' side='right'caption='[[5n0l]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5n0l]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_difficilis"_hall_and_o'toole_1935 "bacillus difficilis" hall and o'toole 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N0L FirstGlance]. <br>
<table><tr><td colspan='2'>[[5n0l]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N0L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">codY, BN1095_790003, BN1096_560190, BN1097_540194 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 "Bacillus difficilis" Hall and O'Toole 1935])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ILE:ISOLEUCINE'>ILE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n0l OCA], [http://pdbe.org/5n0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n0l RCSB], [http://www.ebi.ac.uk/pdbsum/5n0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n0l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n0l OCA], [https://pdbe.org/5n0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n0l RCSB], [https://www.ebi.ac.uk/pdbsum/5n0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n0l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A0A031WD25_CLODI A0A031WD25_CLODI]] DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.[HAMAP-Rule:MF_00621]  
[https://www.uniprot.org/uniprot/Q18BE1_CLOD6 Q18BE1_CLOD6] DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.[HAMAP-Rule:MF_00621]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus difficilis hall and o'toole 1935]]
[[Category: Clostridioides difficile]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Blagova, E V]]
[[Category: Blagova EV]]
[[Category: Levdikov, V M]]
[[Category: Levdikov VM]]
[[Category: Sonenshein, A L]]
[[Category: Sonenshein AL]]
[[Category: Wilkinson, A J]]
[[Category: Wilkinson AJ]]
[[Category: Clostridium]]
[[Category: Gaf domain]]
[[Category: Nutrient sensor]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
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