6hmk: Difference between revisions
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<StructureSection load='6hmk' size='340' side='right'caption='[[6hmk]], [[Resolution|resolution]] 2.06Å' scene=''> | <StructureSection load='6hmk' size='340' side='right'caption='[[6hmk]], [[Resolution|resolution]] 2.06Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6hmk]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6hmk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HMK FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6WK:(2~{R})-2-AZANYL-3-[[(2~{S},3~{S})-2,3-BIS(OXIDANYL)-4-SULFANYL-BUTYL]DISULFANYL]PROPANOIC+ACID'>6WK</scene>, <scene name='pdbligand=7JC:1-methyl-~{N}-(1-methylcyclopropyl)-3-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-bis(oxidanylidene)quinazoline-6-sulfonamide'>7JC</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hmk OCA], [https://pdbe.org/6hmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hmk RCSB], [https://www.ebi.ac.uk/pdbsum/6hmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hmk ProSAT]</span></td></tr> | |||
< | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PARG_HUMAN PARG_HUMAN] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters.<ref>PMID:23102699</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6hmk" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6hmk" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Poly(ADP-ribose) glycohydrolase 3D structures|Poly(ADP-ribose) glycohydrolase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Barkauskaite | [[Category: Barkauskaite E]] | ||
[[Category: Tucker | [[Category: Tucker JA]] | ||
Latest revision as of 11:33, 24 January 2024
POLYADPRIBOSYL GLYCOHYDROLASE IN COMPLEX WITH PDD00016690
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