User:Madeleine Wilson/Sandbox 1: Difference between revisions

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===The N-terminal Domain===
===The N-terminal Domain===
[[Image:Clustal.png|200px|right|thumb|Figure 1. Clustal alignment of N-terminals]]
[[Image:Clustal.png|200px|right|thumb|Figure 1. Clustal alignment of N-terminals]]
The N-terminal domain has no notable function in regard to the activity of KMT; in addition to this, no recent studies have been conducted to discover what the exact function of this region is. As this is a highly conserved region across species, it may be hypothesized this domain plays an integral part in stability.
The N-terminal domain of SET7 is notably far from the active site and has not been shown to be involved in enzyme activity or participate in substrate binding. <ref name="Kwon">PMID: 12514135</ref> With deletion of the N-terminal domain, studies have shown this modification does not affect SET7 activity. <ref name="Xiao" /> Though not essential for catalytic activity, the N-terminal domain by interact with other small molecules or proteins to act as an allosteric regulator region to the C-terminal domain. <ref name="Kwon" />
 


==Inhibitors==
==Inhibitors==
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