User:Madeleine Wilson/Sandbox 1: Difference between revisions
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===The N-terminal Domain=== | ===The N-terminal Domain=== | ||
[[Image:Clustal.png|200px|right|thumb|Figure 1. Clustal alignment of N-terminals]] | [[Image:Clustal.png|200px|right|thumb|Figure 1. Clustal alignment of N-terminals]] | ||
Though a highly conserved region, the N-terminal domain of SET7 is notably far from the active site and has not been shown to be involved in enzyme activity or participate in substrate binding. <ref name="Kwon">PMID: 12514135</ref> With deletion of the N-terminal domain, studies have shown this modification does not affect SET7 activity. <ref name="Xiao" /> Though not essential for catalytic activity, the N-terminal domain may interact with other small molecules or proteins to act as an allosteric regulator region to the C-terminal domain. <ref name="Kwon" /> | Though a highly conserved region, the <scene name='81/811092/N_term_domain/1'>N-terminal domain</scene> of SET7 is notably far from the active site and has not been shown to be involved in enzyme activity or participate in substrate binding. <ref name="Kwon">PMID: 12514135</ref> With deletion of the N-terminal domain, studies have shown this modification does not affect SET7 activity. <ref name="Xiao" /> Though not essential for catalytic activity, the N-terminal domain may interact with other small molecules or proteins to act as an allosteric regulator region to the C-terminal domain. <ref name="Kwon" /> | ||
