YfdX: Difference between revisions

Typhoid fever is a disease that can be spread by contaminated food or water and causes symptoms of lasting fever, weakness, stomach pains, headache, loss of appetite, constipation and sometimes internal bleeding (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017). S. Typhi it is an etiologic agent, the microbial toxin that causes disease in humans. S Typhi is a human restricted disease however, some higher primates can be infected experimentally (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)). S. Typhi is 90% homologous to S Typhimurium but S. Typhimurium can infect both humans and primates (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)). S. Typhi is unique for a couple of small reasons. First S. Typhi has a large region specific to it, Salmonella pathogenicity island 7 that encodes the viaB locus (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)). This locus consists of ten genes related to the biosynthesis and export of Vi polysaccharides capsule (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)). This involves circumventing Toll-Like Receptors mediated immune surveillance (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)). Another area that is specific to S. Typhi is a small island with a locus encoding five genes (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)).  These genes include three typhoid toxins components, a bacteriophage muramidase homolog controlling typhoid toxin secretions and a small gene of unknown function (Chong, A., Lee, S., Yang, Y. A., & Song, J. (2017)).