YfdX: Difference between revisions

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== Where YfdX Comes From ==

YfdX is a product of yfdXWUVE operon and is said to be under the control of <scene name='81/814058/Evga/1'>EvgA</scene>. EvgA come from the EvgAS. EvgAS is a two-component system that modulates drug resistance of E. coli by regulating the expression of the drug transporters <ref name=nishino>PMID: 12670992</ref>. EvgA research has shown that the toxin is made up of 1 molecule of each PltA and CdtB with 5 molecules of PltB <ref name=nishino/>. EvgA is the response regulator and modulates the expression of emrKY, which encodes a bile salt specific exporter and yhiUV which encodes a multidrug exporter <ref name=nishino/> However, over expression of EvgA gives potential an acid resistant phenotype <ref name=nishino/>. The acid resistance is somewhat got in rid of by the deletion of ydeP, yhiE, or ydeO, genes induced by EvgA overexpression <ref name=nishino/>. Along with EvgA most likely planning major role in tolerance to outside forces the yfdXWUVE operon does as well. The yfdXWUVE operon appears to encode proteins that enhance the ability of Salmonella to survive under acidic conditions ~~(Toyota, Cory G., et al)~~.

YfdX is a product of yfdXWUVE operon and is said to be under the control of <scene name='81/814058/Evga/1'>EvgA</scene>. EvgA come from the EvgAS. EvgAS is a two-component system that modulates drug resistance of E. coli by regulating the expression of the drug transporters <ref name=nishino>PMID: 12670992</ref>. EvgA research has shown that the toxin is made up of 1 molecule of each PltA and CdtB with 5 molecules of PltB <ref name=nishino/>. EvgA is the response regulator and modulates the expression of emrKY, which encodes a bile salt specific exporter and yhiUV which encodes a multidrug exporter <ref name=nishino/> However, over expression of EvgA gives potential an acid resistant phenotype <ref name=nishino/>. The acid resistance is somewhat got in rid of by the deletion of ydeP, yhiE, or ydeO, genes induced by EvgA overexpression <ref name=nishino/>. Along with EvgA most likely planning major role in tolerance to outside forces the yfdXWUVE operon does as well. The yfdXWUVE operon appears to encode proteins that enhance the ability of Salmonella to survive under acidic conditions <ref name=cory>PMID: 18245280</ref>.

== Structural highlights of YfdX ==

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 == Where YfdX Comes From ==
-YfdX is a product of yfdXWUVE operon and is said to be under the control of <scene name='81/814058/Evga/1'>EvgA</scene>. EvgA come from the EvgAS. EvgAS is a two-component system that modulates drug resistance of E. coli by regulating the expression of the drug transporters <ref name=nishino>PMID: 12670992</ref>. EvgA research has shown that the toxin is made up of 1 molecule of each PltA and CdtB with 5 molecules of PltB <ref name=nishino/>. EvgA is the response regulator and modulates the expression of emrKY, which encodes a bile salt specific exporter and yhiUV which encodes a multidrug exporter <ref name=nishino/> However, over expression of EvgA gives potential an acid resistant phenotype <ref name=nishino/>. The acid resistance is somewhat got in rid of by the deletion of ydeP, yhiE, or ydeO, genes induced by EvgA overexpression <ref name=nishino/>.  Along with EvgA most likely planning major role in tolerance to outside forces the yfdXWUVE operon does as well. The yfdXWUVE operon appears to encode proteins that enhance the ability of Salmonella to survive under acidic conditions (Toyota, Cory G., et al).
+YfdX is a product of yfdXWUVE operon and is said to be under the control of <scene name='81/814058/Evga/1'>EvgA</scene>. EvgA come from the EvgAS. EvgAS is a two-component system that modulates drug resistance of E. coli by regulating the expression of the drug transporters <ref name=nishino>PMID: 12670992</ref>. EvgA research has shown that the toxin is made up of 1 molecule of each PltA and CdtB with 5 molecules of PltB <ref name=nishino/>. EvgA is the response regulator and modulates the expression of emrKY, which encodes a bile salt specific exporter and yhiUV which encodes a multidrug exporter <ref name=nishino/> However, over expression of EvgA gives potential an acid resistant phenotype <ref name=nishino/>. The acid resistance is somewhat got in rid of by the deletion of ydeP, yhiE, or ydeO, genes induced by EvgA overexpression <ref name=nishino/>.  Along with EvgA most likely planning major role in tolerance to outside forces the yfdXWUVE operon does as well. The yfdXWUVE operon appears to encode proteins that enhance the ability of Salmonella to survive under acidic conditions <ref name=cory>PMID: 18245280</ref>.
 == Structural highlights of YfdX ==