6jxw: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6jxw" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Complex of SUMO2 bound SLS4 from ICP0.== | |||
<StructureSection load='6jxw' size='340' side='right'caption='[[6jxw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jxw]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JXW FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jxw OCA], [http://pdbe.org/6jxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jxw RCSB], [http://www.ebi.ac.uk/pdbsum/6jxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jxw ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Das, R]] | |||
[[Category: Hembram, D S.S]] | |||
[[Category: Negi, H]] | |||
[[Category: Shet, D]] | |||
[[Category: Protein binding-peptide complex]] | |||
[[Category: Sumoylation]] | |||
Revision as of 07:59, 5 February 2020
Complex of SUMO2 bound SLS4 from ICP0.
| ||||||||||||
