6ob6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ob6 is ~~ON HOLD until Paper Publication~~

==Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6ob6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OB6 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBM:6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine'>NBM</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ob6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob6 OCA], [http://pdbe.org/6ob6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ob6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ob6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob6 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/S29A1_HUMAN S29A1_HUMAN]] Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Lee, S Y]]

[[Category: Wright, N J]]

[[Category: Adenosine reuptake inhibitor]]

[[Category: Adenosine transport]]

[[Category: Ent]]

[[Category: Hent1]]

[[Category: Nbmpr]]

[[Category: Nbti]]

[[Category: Nucleoside transport]]

[[Category: Nucleoside-drug transport]]

[[Category: Slc29]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ob6 is ON HOLD  until Paper Publication
+==Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned==
+<StructureSection load='6ob6' size='340' side='right'caption='[[6ob6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ob6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OB6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NBM:6-{[(4-nitrophenyl)methyl]sulfanyl}-9-beta-D-ribofuranosyl-9H-purine'>NBM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ob6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob6 OCA], [http://pdbe.org/6ob6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ob6 RCSB], [http://www.ebi.ac.uk/pdbsum/6ob6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/S29A1_HUMAN S29A1_HUMAN]] Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Lee, S Y]]
+[[Category: Wright, N J]]
+[[Category: Adenosine reuptake inhibitor]]
+[[Category: Adenosine transport]]
+[[Category: Ent]]
+[[Category: Hent1]]
+[[Category: Nbmpr]]
+[[Category: Nbti]]
+[[Category: Nucleoside transport]]
+[[Category: Nucleoside-drug transport]]
+[[Category: Slc29]]
+[[Category: Transport protein]]