6od0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6od0 is ~~ON HOLD~~ ~~until Mar 25 2021~~

==Structure of human CIB1 in complex with peptide inhibitor UNC10245092==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6od0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OD0 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6od0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od0 OCA], [http://pdbe.org/6od0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6od0 RCSB], [http://www.ebi.ac.uk/pdbsum/6od0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6od0 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN]] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Godoy, A S]]

[[Category: Pearce, K]]

[[Category: Puhl, A C]]

[[Category: Cancer]]

[[Category: Cib1]]

[[Category: Metal binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6od0 is ON HOLD  until Mar 25 2021
+==Structure of human CIB1 in complex with peptide inhibitor UNC10245092==
+<StructureSection load='6od0' size='340' side='right'caption='[[6od0]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6od0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OD0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6od0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6od0 OCA], [http://pdbe.org/6od0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6od0 RCSB], [http://www.ebi.ac.uk/pdbsum/6od0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6od0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN]] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Godoy, A S]]
+[[Category: Pearce, K]]
+[[Category: Puhl, A C]]
+[[Category: Cancer]]
+[[Category: Cib1]]
+[[Category: Metal binding protein]]