6oik: Difference between revisions
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==Muscarinic acetylcholine receptor 2-Go complex== | |||
<StructureSection load='6oik' size='340' side='right'caption='[[6oik]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6oik]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OIK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oik OCA], [http://pdbe.org/6oik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oik RCSB], [http://www.ebi.ac.uk/pdbsum/6oik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oik ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> [[http://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Kobilka, B]] | |||
[[Category: Maeda, S]] | [[Category: Maeda, S]] | ||
[[Category: Qianhui, Q]] | [[Category: Qianhui, Q]] | ||
[[Category: | [[Category: Skiniotis, G]] | ||
[[Category: G-protein coupled receptor-g-protein complex]] | |||
[[Category: Neurotransmitter receptor]] | |||
[[Category: Signaling protein]] | |||
Revision as of 11:24, 10 May 2019
Muscarinic acetylcholine receptor 2-Go complex
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