1lbd: Difference between revisions

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[[Image:1lbd.gif|left|200px]]
{{Seed}}
[[Image:1lbd.png|left|200px]]


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{{STRUCTURE_1lbd|  PDB=1lbd  |  SCENE=  }}  
{{STRUCTURE_1lbd|  PDB=1lbd  |  SCENE=  }}  


'''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''
===LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA===




==Overview==
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The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
The line below this paragraph, {{ABSTRACT_PUBMED_7760929}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7760929}}


==About this Structure==
==About this Structure==
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[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:07:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 12:13:48 2008''

Revision as of 09:13, 2 July 2008

File:1lbd.png

Template:STRUCTURE 1lbd

LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA

Template:ABSTRACT PUBMED 7760929

About this Structure

1LBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha., Bourguet W, Ruff M, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Jun 1;375(6530):377-82. PMID:7760929

Page seeded by OCA on Wed Jul 2 12:13:48 2008

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