6oov: Difference between revisions
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==Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA== | |||
<StructureSection load='6oov' size='340' side='right'caption='[[6oov]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6oov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OOV FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
[[Category: | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HMCES, C3orf37, DC12, SRAPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
[[Category: Arrowsmith, C | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oov OCA], [http://pdbe.org/6oov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oov RCSB], [http://www.ebi.ac.uk/pdbsum/6oov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oov ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Edwards, A M]] | |||
[[Category: Halabelian, L]] | |||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: Zeng, H]] | ||
[[Category: | [[Category: 3' overhang]] | ||
[[Category: | [[Category: Dna binding protein]] | ||
[[Category: | [[Category: Dna binding protein-dna complex]] | ||
[[Category: Dna-damage protein]] | |||
[[Category: Dna-protein complex]] | |||
[[Category: Hmce]] | |||
[[Category: Sgc]] | |||
[[Category: Srap domain]] | |||
Revision as of 07:36, 21 May 2019
Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
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