YfdX: Difference between revisions

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== Introduction ==

<scene name='81/814058/Yfdx/6'>YfdX</scene> is a family protein that is encoded by several pathogenic bacteria such as Salmonella and E. coli. Particularly YfdX is encoded in Salmonella enterica serovar Typhi that causes a fatal disease called Typhoid Fever. Typhoid fever is a disease that can be spread by contaminated food or water and causes symptoms of lasting fever, weakness, stomach pains, headache, loss of appetite, constipation and sometimes internal bleeding <ref name=chong>PMID: 28656014</ref>. S. Typhi it is an etiologic agent, the microbial toxin that causes disease in humans. S Typhi is a human restricted disease however, some higher primates can be infected experimentally <ref name=chong/>. S. Typhi is 90% homologous to S Typhimurium but S. Typhimurium can infect both humans and primates <ref name=chong/>. S. Typhi is unique for a couple of small reasons. First S. Typhi has a large region specific to it, Salmonella pathogenicity island 7 that encodes the viaB locus <ref name=chong/>. This locus consists of ten genes related to the biosynthesis and export of Vi polysaccharides capsule <ref name=chong/>. This involves circumventing Toll-Like Receptors mediated immune surveillance <ref name=chong/>. Another area that is specific to S. Typhi is a small island with a locus encoding five genes <ref name=chong/>. These genes include three typhoid toxins components, a bacteriophage muramidase homolog controlling typhoid toxin secretions and a small gene of unknown function <ref name=chong/>.

<scene name='81/814058/Yfdx/6'>YfdX</scene> is a family protein that is encoded by several pathogenic bacteria such as Salmonella and E coli. Particularly YfdX is encoded in Salmonella enterica serovar Typhi that causes a fatal disease called Typhoid Fever. Typhoid fever is a disease that can be spread by contaminated food or water and causes symptoms of lasting fever, weakness, stomach pains, headache, loss of appetite, constipation and sometimes internal bleeding <ref name=chong>PMID: 28656014</ref>. S. Typhi it is an etiologic agent, the microbial toxin that causes disease in humans. S Typhi is a human restricted disease however, some higher primates can be infected experimentally <ref name=chong/>. S. Typhi is 90% homologous to S Typhimurium but S. Typhimurium can infect both humans and primates <ref name=chong/>. S. Typhi is unique for a couple of small reasons. First S. Typhi has a large region specific to it, Salmonella pathogenicity island 7 that encodes the viaB locus <ref name=chong/>. This locus consists of ten genes related to the biosynthesis and export of Vi polysaccharides capsule <ref name=chong/>. This involves circumventing Toll-Like Receptors mediated immune surveillance <ref name=chong/>. Another area that is specific to S. Typhi is a small island with a locus encoding five genes <ref name=chong/>. These genes include three typhoid toxins components, a bacteriophage muramidase homolog controlling typhoid toxin secretions and a small gene of unknown function <ref name=chong/>.

== Toxicity of Typhoid Toxin ==

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 == Introduction ==
-<scene name='81/814058/Yfdx/6'>YfdX</scene> is a family protein that is encoded by several pathogenic bacteria such as Salmonella and E. coli. Particularly YfdX is encoded in Salmonella enterica serovar Typhi that causes a fatal disease called Typhoid Fever. Typhoid fever is a disease that can be spread by contaminated food or water and causes symptoms of lasting fever, weakness, stomach pains, headache, loss of appetite, constipation and sometimes internal bleeding <ref name=chong>PMID: 28656014</ref>. S. Typhi it is an etiologic agent, the microbial toxin that causes disease in humans. S Typhi is a human restricted disease however, some higher primates can be infected experimentally <ref name=chong/>. S. Typhi is 90% homologous to S Typhimurium but S. Typhimurium can infect both humans and primates <ref name=chong/>. S. Typhi is unique for a couple of small reasons. First S. Typhi has a large region specific to it, Salmonella pathogenicity island 7 that encodes the viaB locus <ref name=chong/>. This locus consists of ten genes related to the biosynthesis and export of Vi polysaccharides capsule <ref name=chong/>. This involves circumventing Toll-Like Receptors mediated immune surveillance <ref name=chong/>. Another area that is specific to S. Typhi is a small island with a locus encoding five genes <ref name=chong/>.  These genes include three typhoid toxins components, a bacteriophage muramidase homolog controlling typhoid toxin secretions and a small gene of unknown function <ref name=chong/>.
+<scene name='81/814058/Yfdx/6'>YfdX</scene> is a family protein that is encoded by several pathogenic bacteria such as Salmonella and E coli. Particularly YfdX is encoded in Salmonella enterica serovar Typhi that causes a fatal disease called Typhoid Fever. Typhoid fever is a disease that can be spread by contaminated food or water and causes symptoms of lasting fever, weakness, stomach pains, headache, loss of appetite, constipation and sometimes internal bleeding <ref name=chong>PMID: 28656014</ref>. S. Typhi it is an etiologic agent, the microbial toxin that causes disease in humans. S Typhi is a human restricted disease however, some higher primates can be infected experimentally <ref name=chong/>. S. Typhi is 90% homologous to S Typhimurium but S. Typhimurium can infect both humans and primates <ref name=chong/>. S. Typhi is unique for a couple of small reasons. First S. Typhi has a large region specific to it, Salmonella pathogenicity island 7 that encodes the viaB locus <ref name=chong/>. This locus consists of ten genes related to the biosynthesis and export of Vi polysaccharides capsule <ref name=chong/>. This involves circumventing Toll-Like Receptors mediated immune surveillance <ref name=chong/>. Another area that is specific to S. Typhi is a small island with a locus encoding five genes <ref name=chong/>.  These genes include three typhoid toxins components, a bacteriophage muramidase homolog controlling typhoid toxin secretions and a small gene of unknown function <ref name=chong/>.
 == Toxicity of Typhoid Toxin ==