Sandbox Reserved 1546: Difference between revisions
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<StructureSection load='1stp' size='340' side='right' caption='5H86 Structure' scene='80/806432/5h86_molecule/2'> | <StructureSection load='1stp' size='340' side='right' caption='5H86 Structure' scene='80/806432/5h86_molecule/2'> | ||
===Structure=== | |||
The enzyme, 5h86, can be expressed in ''E. coli'' and is found in humans <ref name = "Structural basis for acyl-group discrimination by human Gcn5L2"/>. The characteristics of this 5h86 Human Gcn5 enzyme bound to butyrl-coA can be summarized in the table below. Clicking on each green linked element will convey important structural information of the enzyme. | The enzyme, 5h86, can be expressed in ''E. coli'' and is found in humans <ref name = "Structural basis for acyl-group discrimination by human Gcn5L2"/>. The characteristics of this 5h86 Human Gcn5 enzyme bound to butyrl-coA can be summarized in the table below. Clicking on each green linked element will convey important structural information of the enzyme. | ||
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<tr id='activity'><td class="sblockLbl"><b>Type of Enzymatic Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase]</span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Type of Enzymatic Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB 5h86 PDB][http://proteopedia.org/wiki/index.php/5h86#cite_note-0 5h86 Proteopedia Page]</span></td></tr> | ||
</table></center> | </table></center> | ||
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<p> There are <scene name='80/806432/Ligands/1'>two ligand binding sites</scene>, which can be represented in green and the protein structure is represented by a khaki color. The active site of Gcn5 contains two binding grooves where acetyl-CoA and peptide bind, Butyrul CoEnzyme A <scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>(BCO)</scene> & 1,2-Ethanediol <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>(EDO)</scene>.</p> | <p> There are <scene name='80/806432/Ligands/1'>two ligand binding sites</scene>, which can be represented in green and the protein structure is represented by a khaki color. The active site of Gcn5 contains two binding grooves where acetyl-CoA and peptide bind, Butyrul CoEnzyme A <scene name='pdbligand=BCO:BUTYRYL+COENZYME+A'>(BCO)</scene> & 1,2-Ethanediol <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>(EDO)</scene>.</p> | ||
===Disease Relevance=== | |||
Since this enzyme is found in ''Homo sapiens'', or humans, and is a Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5">doi: 10.1073/pnas.0607378104</ref><ref name = "The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development">doi: 10.1128/MCB.01599-08</ref>. | |||
</StructureSection> | </StructureSection> | ||
