Sandbox Reserved 1546: Difference between revisions

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<tr id='activity'><td class="sblockLbl">Type of Enzymatic Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB 5h86 PDB][http://proteopedia.org/wiki/index.php/5h86#cite_note-0 5h86 Proteopedia Page]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB 5h86 PDB], [http://proteopedia.org/wiki/index.php/5h86#cite_note-0 5h86 Proteopedia Page]</td></tr>

</table></center>

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===Disease Relevance===

Since this enzyme is found in ''Homo sapiens'', or humans, and is a Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5">doi: 10.1073/pnas.0607378104</ref><ref name = "The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development">doi: 10.1128/MCB.01599-08</ref>.

Since this enzyme is found in ''Homo sapiens'', or humans, and is a HAT Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a probable role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5">doi: 10.1073/pnas.0607378104</ref><ref name = "The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development">doi: 10.1128/MCB.01599-08</ref>.

</StructureSection>

Sandbox Reserved 1546: Difference between revisions

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@@ Line 42: / Line 42: @@
 <tr id='activity'><td class="sblockLbl"><b>Type of Enzymatic Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB 5h86 PDB][http://proteopedia.org/wiki/index.php/5h86#cite_note-0 5h86 Proteopedia Page]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://www.rcsb.org/pdb/explore.do?structureId=5h86 RCSB 5h86 PDB], [http://proteopedia.org/wiki/index.php/5h86#cite_note-0 5h86 Proteopedia Page]</span></td></tr>
 </table></center>
@@ Line 53: / Line 53: @@
 ===Disease Relevance===
-Since this enzyme is found in ''Homo sapiens'', or humans, and is a Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5">doi: 10.1073/pnas.0607378104</ref><ref name = "The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development">doi: 10.1128/MCB.01599-08</ref>.
+Since this enzyme is found in ''Homo sapiens'', or humans, and is a HAT Gcn5 bound to butyryl-CoA, the 5h86 enzyme has also been found to have a probable role in HIV-1 infections by being able to utilize the recruited viral protein "Tat" to regulate the activity that induces proviral gene chromatin remodeling <ref name = "Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5">doi: 10.1073/pnas.0607378104</ref><ref name = "The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development">doi: 10.1128/MCB.01599-08</ref>.
 </StructureSection>