6om2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6om2 is ~~ON HOLD until Paper Publication~~

==Crystal structure of atypical integrin alphaV beta8 with proTGF-beta1 ligand peptide==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6om2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OM2 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6om2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6om2 OCA], [http://pdbe.org/6om2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6om2 RCSB], [http://www.ebi.ac.uk/pdbsum/6om2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6om2 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN]] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [[http://www.uniprot.org/uniprot/ITB8_HUMAN ITB8_HUMAN]] Integrin alpha-V/beta-8 is a receptor for fibronectin.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Springer, T A]]

[[Category: Wang, J C]]

[[Category: Immune system]]

[[Category: Integrin]]

[[Category: Tgf-beta activation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6om2 is ON HOLD  until Paper Publication
+==Crystal structure of atypical integrin alphaV beta8 with proTGF-beta1 ligand peptide==
+<StructureSection load='6om2' size='340' side='right'caption='[[6om2]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6om2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OM2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6om2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6om2 OCA], [http://pdbe.org/6om2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6om2 RCSB], [http://www.ebi.ac.uk/pdbsum/6om2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6om2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN]] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [[http://www.uniprot.org/uniprot/ITB8_HUMAN ITB8_HUMAN]] Integrin alpha-V/beta-8 is a receptor for fibronectin.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Springer, T A]]
+[[Category: Wang, J C]]
+[[Category: Immune system]]
+[[Category: Integrin]]
+[[Category: Tgf-beta activation]]