6rjp: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6rjp is ~~ON HOLD~~

==Bfl-1 in complex with alpha helical peptide==

~~Authors~~: ~~Baggio~~, C., ~~Gambini, L~~., ~~Udompholkul, P~~.~~, Salem, A~~.F., ~~Hakansson, M~~.~~, Jossart, J~~., ~~Perry, J~~.~~, Pellecchia, M~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6rjp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJP FirstGlance]. <br>

~~Description~~: ~~Bfl~~-1 in ~~complex with alpha helical peptide~~

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=LV8:'>LV8</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjp OCA], [http://pdbe.org/6rjp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rjp RCSB], [http://www.ebi.ac.uk/pdbsum/6rjp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjp ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Baggio, C]]

[[Category: Gambini, L]]

[[Category: Hakansson, M]]

[[Category: Jossart, J]]

[[Category: Pellecchia, M]]

[[Category: ~~Jossart~~, J]]

[[Category: Perry, J]]

~~[[Category: Gambini, L~~]]

[[Category: Salem, A F]]

[[Category: Salem, A.F]]

[[Category: Udompholkul, P]]

[[Category: ~~Perry, J~~]]

[[Category: Bcl2-2 family protein]]

[[Category: ~~Hakansson, M~~]]

[[Category: Covalent inhibitor]]

[[Category: Peptide binding protein]]

[[Category: Protein-protein interaction]]

[[Category: Stapled alpha helix]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6rjp is ON HOLD
+==Bfl-1 in complex with alpha helical peptide==
+<StructureSection load='6rjp' size='340' side='right'caption='[[6rjp]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
-Authors: Baggio, C., Gambini, L., Udompholkul, P., Salem, A.F., Hakansson, M., Jossart, J., Perry, J., Pellecchia, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rjp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RJP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RJP FirstGlance]. <br>
-Description: Bfl-1 in complex with alpha helical peptide
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=LV8:'>LV8</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rjp OCA], [http://pdbe.org/6rjp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rjp RCSB], [http://www.ebi.ac.uk/pdbsum/6rjp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rjp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Baggio, C]]
+[[Category: Gambini, L]]
+[[Category: Hakansson, M]]
+[[Category: Jossart, J]]
 [[Category: Pellecchia, M]]
-[[Category: Jossart, J]]
+[[Category: Perry, J]]
-[[Category: Gambini, L]]
+[[Category: Salem, A F]]
-[[Category: Salem, A.F]]
 [[Category: Udompholkul, P]]
-[[Category: Perry, J]]
+[[Category: Bcl2-2 family protein]]
-[[Category: Hakansson, M]]
+[[Category: Covalent inhibitor]]
+[[Category: Peptide binding protein]]
+[[Category: Protein-protein interaction]]
+[[Category: Stapled alpha helix]]