4uzb: Difference between revisions
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<StructureSection load='4uzb' size='340' side='right'caption='[[4uzb]], [[Resolution|resolution]] 2.87Å' scene=''> | <StructureSection load='4uzb' size='340' side='right'caption='[[4uzb]], [[Resolution|resolution]] 2.87Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UZB FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [https://pdbe.org/4uzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [https://www.ebi.ac.uk/pdbsum/4uzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uzb ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/LANA1_HHV8P LANA1_HHV8P] Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472). Promotes nuclear localization and cleavage of host STAT6 leading to constitutive activation of the IL13/STAT6 signaling pathway to promote viral latency (PubMed:28099521). Interacts with and modulates the histone methyltransferase MLL1 complex activity, leading to its recruitment on viral DNA terminal repeats changing the dynamic of histone H3 methylated 'Lys-4'(H3K4me) profile during the initial hours following infection (PubMed:34850113).<ref>PMID:10213686</ref> <ref>PMID:16227282</ref> <ref>PMID:16469929</ref> <ref>PMID:21697472</ref> <ref>PMID:24741090</ref> <ref>PMID:25995248</ref> <ref>PMID:26223641</ref> <ref>PMID:27599637</ref> <ref>PMID:28099521</ref> <ref>PMID:28696226</ref> <ref>PMID:34850113</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human gammaherpesvirus 8]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hellert | [[Category: Hellert J]] | ||
[[Category: Krausze | [[Category: Krausze J]] | ||
[[Category: Luhrs | [[Category: Luhrs T]] | ||
