2b1u: Difference between revisions

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[[Image:2b1u.gif|left|200px]]
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[[Image:2b1u.png|left|200px]]


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{{STRUCTURE_2b1u|  PDB=2b1u  |  SCENE=  }}  
{{STRUCTURE_2b1u|  PDB=2b1u  |  SCENE=  }}  


'''Solution structure of Calmodulin-like Skin Protein C terminal domain'''
===Solution structure of Calmodulin-like Skin Protein C terminal domain===




==Overview==
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The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy. The mobility of CLSP has been found to be different for the N-terminal and C-terminal domains. The isolated domains were also expressed and analyzed. The structure of the isolated C-terminal domain is presented. The N-terminal domain is characterized by four stable helices, which experience large fluctuations. This is shown to be due to mutations in the hydrophobic core. The overall N-terminal domain behavior is similar both in the full-length protein and in the isolated domain. By exploiting the capability of Tb3+ bound to CLSP to induce partial orientation of the molecule in a magnetic field, restricted motion of one domain with respect to the other was proved. By using NMR, ITC, and ESI-MS, the calcium and magnesium binding properties were investigated. Finally, CLSP is framed into the evolutionary scheme of the calmodulin-like family.
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{{ABSTRACT_PUBMED_16765896}}


==About this Structure==
==About this Structure==
2B1U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1U OCA].  
2B1U is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1U OCA].  


==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structural proteomics in europe]]
[[Category: Structural proteomics in europe]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:17:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:05:02 2008''

Revision as of 13:05, 29 July 2008

File:2b1u.png

Template:STRUCTURE 2b1u

Solution structure of Calmodulin-like Skin Protein C terminal domain

Template:ABSTRACT PUBMED 16765896

About this Structure

2B1U is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

A structural and dynamic characterization of the EF-hand protein CLSP., Babini E, Bertini I, Capozzi F, Chirivino E, Luchinat C, Structure. 2006 Jun;14(6):1029-38. PMID:16765896

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