6k1b: Difference between revisions
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==Crystal structure of EXD2 exonuclease domain soaked in Mn and dGMP== | |||
<StructureSection load='6k1b' size='340' side='right'caption='[[6k1b]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6k1b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K1B FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_I Exodeoxyribonuclease I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.1 3.1.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k1b OCA], [http://pdbe.org/6k1b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k1b RCSB], [http://www.ebi.ac.uk/pdbsum/6k1b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k1b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/EXD2_HUMAN EXD2_HUMAN]] Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.<ref>PMID:20603073</ref> <ref>PMID:26807646</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Exodeoxyribonuclease I]] | |||
[[Category: Large Structures]] | |||
[[Category: Lee, C]] | [[Category: Lee, C]] | ||
[[Category: Park, J]] | [[Category: Park, J]] | ||
[[Category: 3'-5' exonuclease]] | |||
[[Category: Dnaq family]] | |||
[[Category: Hydrolase]] | |||
Revision as of 06:51, 23 May 2019
Crystal structure of EXD2 exonuclease domain soaked in Mn and dGMP
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