6ov7: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6ov7 is ~~ON HOLD~~ ~~until Paper Publication~~

==CFTR Associated Ligand (CAL) PDZ domain bound to peptide kCAL01==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6ov7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OV7 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ov7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ov7 OCA], [http://pdbe.org/6ov7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ov7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ov7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ov7 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>

== Function ==

[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Gill, N P]]

[[Category: Madden, D R]]

[[Category: Complex]]

[[Category: Inhibitor]]

[[Category: Pdz domain]]

[[Category: Peptide binding protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ov7 is ON HOLD  until Paper Publication
+==CFTR Associated Ligand (CAL) PDZ domain bound to peptide kCAL01==
+<StructureSection load='6ov7' size='340' side='right'caption='[[6ov7]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ov7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OV7 FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ov7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ov7 OCA], [http://pdbe.org/6ov7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ov7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ov7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ov7 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Gill, N P]]
+[[Category: Madden, D R]]
+[[Category: Complex]]
+[[Category: Inhibitor]]
+[[Category: Pdz domain]]
+[[Category: Peptide binding protein]]