6mo2: Difference between revisions
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<StructureSection load='6mo2' size='340' side='right'caption='[[6mo2]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='6mo2' size='340' side='right'caption='[[6mo2]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6mo2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6mo2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MO2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JVM:1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine'>JVM</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JVM:1-(4-{5-[(piperidin-4-yl)methoxy]-3-[4-(1H-pyrazol-4-yl)phenyl]pyrazin-2-yl}phenyl)methanamine'>JVM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mo2 OCA], [https://pdbe.org/6mo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mo2 RCSB], [https://www.ebi.ac.uk/pdbsum/6mo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mo2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0B4L2Y4_9FLAV A0A0B4L2Y4_9FLAV] [https://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6mo2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6mo2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Virus protease 3D structures|Virus protease 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Dengue virus 2]] | [[Category: Dengue virus 2]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Hua | [[Category: Hua Y]] | ||
[[Category: Huo | [[Category: Huo T]] | ||
[[Category: Lin | [[Category: Lin Y-L]] | ||
[[Category: Nie | [[Category: Nie S]] | ||
[[Category: Song | [[Category: Song Y]] | ||
[[Category: Wu | [[Category: Wu F]] | ||
[[Category: Wu | [[Category: Wu J]] | ||
[[Category: Yao | [[Category: Yao Y]] | ||
Latest revision as of 06:35, 11 October 2023
Structure of dengue virus protease with an allosteric Inhibitor that blocks replication
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