6oov: Difference between revisions
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<StructureSection load='6oov' size='340' side='right'caption='[[6oov]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='6oov' size='340' side='right'caption='[[6oov]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6oov]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6oov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OOV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oov OCA], [https://pdbe.org/6oov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oov RCSB], [https://www.ebi.ac.uk/pdbsum/6oov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oov ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Synthetic construct]] | ||
[[Category: Bountra | [[Category: Arrowsmith CH]] | ||
[[Category: Edwards | [[Category: Bountra C]] | ||
[[Category: Halabelian | [[Category: Edwards AM]] | ||
[[Category: Li | [[Category: Halabelian L]] | ||
[[Category: Li Y]] | |||
[[Category: Zeng | [[Category: Zeng H]] | ||
Latest revision as of 07:14, 11 October 2023
Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA
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