4ufc

Crystal structure of the GH95 enzyme BACOVA_03438

spinqualitylabelsall models 4ufc, resolution 2.81Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ufc is a 2 chain structure with sequence from Bacteroides ovatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, CAC, GIV Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A7M011_BACO1 Publication Abstract from PubMed The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which carbohydrate breakdown products are shared between members of the microbiota is unclear. We show here, using xylan as a model, that sharing the breakdown products of complex carbohydrates by key members of the microbiota, such as Bacteroides ovatus, is dependent on the complexity of the target glycan. Characterization of the extensive xylan degrading apparatus expressed by B. ovatus reveals that the breakdown of the polysaccharide by the human gut microbiota is significantly more complex than previous models suggested, which were based on the deconstruction of xylans containing limited monosaccharide side chains. Our report presents a highly complex and dynamic xylan degrading apparatus that is fine-tuned to recognize the different forms of the polysaccharide presented to the human gut microbiota. Glycan complexity dictates microbial resource allocation in the large intestine.,Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Basle A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN Nat Commun. 2015 Jun 26;6:7481. doi: 10.1038/ncomms8481. PMID:26112186 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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