6a8o: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6a8o is ~~ON HOLD until Paper Publication~~

==Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16==

~~Authors~~: Xu, M., ~~Jiang~~, L., ~~Huang~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[6a8o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A8O OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A8O FirstGlance].

~~Description~~: ~~Crystal structures of~~ the ~~serine protease domain of murine plasma kallikrein~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a8o OCA], [http://pdbe.org/6a8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a8o RCSB], [http://www.ebi.ac.uk/pdbsum/6a8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a8o ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/KLKB1_MOUSE KLKB1_MOUSE]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Plasma kallikrein]]

[[Category: Huang, M]]

[[Category: Jiang, L]]

[[Category: Xu, M]]

[[Category: Hydrolase]]

[[Category: Murine plasma kallikrein]]

[[Category: Serine protease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6a8o is ON HOLD  until Paper Publication
+==Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16==
+<StructureSection load='6a8o' size='340' side='right'caption='[[6a8o]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
-Authors: Xu, M., Jiang, L., Huang, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6a8o]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A8O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A8O FirstGlance]. <br>
-Description: Crystal structures of the serine protease domain of murine plasma kallikrein
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a8o OCA], [http://pdbe.org/6a8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a8o RCSB], [http://www.ebi.ac.uk/pdbsum/6a8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a8o ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KLKB1_MOUSE KLKB1_MOUSE]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Plasma kallikrein]]
 [[Category: Huang, M]]
 [[Category: Jiang, L]]
 [[Category: Xu, M]]
+[[Category: Hydrolase]]
+[[Category: Murine plasma kallikrein]]
+[[Category: Serine protease]]