6jzc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6jzc is ~~ON HOLD~~ ~~until Paper Publication~~

==Structural basis of tubulin detyrosination==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6jzc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JZC FirstGlance].

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase Tubulinyl-Tyr carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.17 3.4.17.17] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jzc OCA], [http://pdbe.org/6jzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jzc RCSB], [http://www.ebi.ac.uk/pdbsum/6jzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jzc ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/VASH2_MOUSE VASH2_MOUSE]] Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).<ref>PMID:19204325</ref> <ref>PMID:29146868</ref> [[http://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN]] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Tubulinyl-Tyr carboxypeptidase]]

[[Category: Chen, Z]]

[[Category: Ling, Y]]

[[Category: Zeyuan, G]]

[[Category: Zhu, L]]

[[Category: Cytosolic protein]]

[[Category: Svbp]]

[[Category: Tubulin detyrosination]]

[[Category: Vash2]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6jzc is ON HOLD  until Paper Publication
+==Structural basis of tubulin detyrosination==
+<StructureSection load='6jzc' size='340' side='right'caption='[[6jzc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6jzc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JZC FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase Tubulinyl-Tyr carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.17 3.4.17.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jzc OCA], [http://pdbe.org/6jzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jzc RCSB], [http://www.ebi.ac.uk/pdbsum/6jzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jzc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/VASH2_MOUSE VASH2_MOUSE]] Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146868). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325).<ref>PMID:19204325</ref> <ref>PMID:29146868</ref>  [[http://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN]] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Tubulinyl-Tyr carboxypeptidase]]
+[[Category: Chen, Z]]
+[[Category: Ling, Y]]
+[[Category: Zeyuan, G]]
+[[Category: Zhu, L]]
+[[Category: Cytosolic protein]]
+[[Category: Svbp]]
+[[Category: Tubulin detyrosination]]
+[[Category: Vash2]]