6k3a: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6k3a is ~~ON HOLD~~

==Crystal structure of human PCNA in complex with DNMT1 PIP box motif.==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6k3a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K3A FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3a OCA], [http://pdbe.org/6k3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k3a RCSB], [http://www.ebi.ac.uk/pdbsum/6k3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3a ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Arita, K]]

[[Category: Jimenji, T]]

[[Category: Kori, S]]

[[Category: Dna methylation]]

[[Category: Dnmt1]]

[[Category: Pcna]]

[[Category: Pip box]]

[[Category: Replication]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6k3a is ON HOLD
+==Crystal structure of human PCNA in complex with DNMT1 PIP box motif.==
+<StructureSection load='6k3a' size='340' side='right'caption='[[6k3a]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6k3a]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6K3A FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6k3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k3a OCA], [http://pdbe.org/6k3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k3a RCSB], [http://www.ebi.ac.uk/pdbsum/6k3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k3a ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Arita, K]]
+[[Category: Jimenji, T]]
+[[Category: Kori, S]]
+[[Category: Dna methylation]]
+[[Category: Dnmt1]]
+[[Category: Pcna]]
+[[Category: Pip box]]
+[[Category: Replication]]