4uwh: Difference between revisions

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<StructureSection load='4uwh' size='340' side='right'caption='[[4uwh]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='4uwh' size='340' side='right'caption='[[4uwh]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4uwh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UWH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4uwh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UWH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JXM:(8S)-9-[(2R)-2-HYDROXY-2-PHENYLETHYL]-2-(MORPHOLIN-4-YL)-8-(TRIFLUOROMETHYL)-6,7,8,9-TETRAHYDRO-4H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>JXM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JXM:(8S)-9-[(2R)-2-HYDROXY-2-PHENYLETHYL]-2-(MORPHOLIN-4-YL)-8-(TRIFLUOROMETHYL)-6,7,8,9-TETRAHYDRO-4H-PYRIMIDO[1,2-A]PYRIMIDIN-4-ONE'>JXM</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uwk|4uwk]], [[4uwl|4uwl]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwh OCA], [https://pdbe.org/4uwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uwh RCSB], [https://www.ebi.ac.uk/pdbsum/4uwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwh ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwh OCA], [http://pdbe.org/4uwh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uwh RCSB], [http://www.ebi.ac.uk/pdbsum/4uwh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Abecassis PY]]
[[Category: Abecassis, P Y]]
[[Category: Arigon J]]
[[Category: Arigon, J]]
[[Category: Barriere C]]
[[Category: Barriere, C]]
[[Category: Benard T]]
[[Category: Benard, T]]
[[Category: Bertin L]]
[[Category: Bertin, L]]
[[Category: Bertrand T]]
[[Category: Bertrand, T]]
[[Category: Bretin F]]
[[Category: Bretin, F]]
[[Category: Brollo M]]
[[Category: Brollo, M]]
[[Category: Caron A]]
[[Category: Caron, A]]
[[Category: Castell C]]
[[Category: Castell, C]]
[[Category: Clement J]]
[[Category: Clement, J]]
[[Category: Combet R]]
[[Category: Combet, R]]
[[Category: Delbarre L]]
[[Category: Delbarre, L]]
[[Category: Durand F]]
[[Category: Durand, F]]
[[Category: Dureuil C]]
[[Category: Dureuil, C]]
[[Category: El-Ahmad Y]]
[[Category: El-Ahmad, Y]]
[[Category: ElBatti S]]
[[Category: ElBatti, S]]
[[Category: Fassy F]]
[[Category: Fassy, F]]
[[Category: Filoche-Romme B]]
[[Category: Filoche-Romme, B]]
[[Category: Garcia-Echeverria C]]
[[Category: Garcia-Echeverria, C]]
[[Category: Gay F]]
[[Category: Gay, F]]
[[Category: Goulaouic H]]
[[Category: Goulaouic, H]]
[[Category: Labrosse JR]]
[[Category: Labrosse, J R]]
[[Category: Lefrancois D]]
[[Category: Lefrancois, D]]
[[Category: Leroy V]]
[[Category: Leroy, V]]
[[Category: Letallec JP]]
[[Category: Letallec, J P]]
[[Category: Loyau V]]
[[Category: Loyau, V]]
[[Category: Marquette JP]]
[[Category: Marquette, J P]]
[[Category: Mathieu M]]
[[Category: Mathieu, M]]
[[Category: McCort G]]
[[Category: McCort, G]]
[[Category: Michot N]]
[[Category: Michot, N]]
[[Category: Pasquier B]]
[[Category: Pasquier, B]]
[[Category: Perraut P]]
[[Category: Perraut, P]]
[[Category: Pilorge F]]
[[Category: Pilorge, F]]
[[Category: Richepin P]]
[[Category: Richepin, P]]
[[Category: Ronan B]]
[[Category: Ronan, B]]
[[Category: Schio L]]
[[Category: Schio, L]]
[[Category: Sonnefraud V]]
[[Category: Sonnefraud, V]]
[[Category: Autophagy inhibitor]]
[[Category: Lipid kinase]]
[[Category: Transferase]]