4xnw: Difference between revisions

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<StructureSection load='4xnw' size='340' side='right'caption='[[4xnw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4xnw' size='340' side='right'caption='[[4xnw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4xnw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pasteurianus"_(winogradsky_1895)_lehmann_and_neumann_1907 "bacillus pasteurianus" (winogradsky 1895) lehmann and neumann 1907]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XNW FirstGlance]. <br>
<table><tr><td colspan='2'>[[4xnw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_pasteurianum Clostridium pasteurianum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XNW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ID:[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ID</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ID:[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ID</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xnv|4xnv]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xnw OCA], [https://pdbe.org/4xnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xnw RCSB], [https://www.ebi.ac.uk/pdbsum/4xnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xnw ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P2RY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1501 "Bacillus pasteurianus" (Winogradsky 1895) Lehmann and Neumann 1907])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xnw OCA], [http://pdbe.org/4xnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xnw RCSB], [http://www.ebi.ac.uk/pdbsum/4xnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xnw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN]] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref>
[https://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref> [https://www.uniprot.org/uniprot/RUBR_CLOPA RUBR_CLOPA] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clostridium pasteurianum]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: GPCR, GPCR Network]]
[[Category: Gao Z]]
[[Category: Gao, Z]]
[[Category: Han GW]]
[[Category: Han, G W]]
[[Category: Jacobson K]]
[[Category: Jacobson, K]]
[[Category: Stevens R]]
[[Category: Stevens, R]]
[[Category: Wu B]]
[[Category: Wu, B]]
[[Category: Zhang D]]
[[Category: Zhang, D]]
[[Category: Zhao Q]]
[[Category: Zhao, Q]]
[[Category: G protein coupled receptor]]
[[Category: Gpcr]]
[[Category: Gpcr network]]
[[Category: Human p2y1 receptor]]
[[Category: Membrane protein]]
[[Category: Platelet activation]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]
[[Category: Transport protein]]