Parkin

Structure

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Domains: RING0, RING1, RING2, IBR, UBL. Function Parkin is an E3 ubiquitin ligase involved in mitophagy via the Pink1-Parkin pathway. Parkin can also act as a transcription factor, downregulating, for instance, the expression of p53 and PS2, and upregulating the expression of PS1. Disease Mutations in the Parkin gene are widely associated with recessive juvenile Parkinson's disease forms. Being involved in autophagy via ubiquitinylation and in transcriptional repression of important cell cycle and amyloidogenic genes, it is also implied in Alzheimer's disease forms. Relevance Parkin acts as a repressor for p53, which is an important cell cycle regulator, and as a repressor for PS2 and activator of PS1 expression, which are proteins involved in the γ-secretase complex, which is one of the components in the amyloidogenic pathway. Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Proteopedia Page Contributors and Editors (what is this?)

Alan Moreira Henrique, Michal Harel, Leonardo C. Cardoso