6ony: Difference between revisions
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==BRD2_Bromodomain1 complex with inhibitor 744== | |||
<StructureSection load='6ony' size='340' side='right'caption='[[6ony]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ony]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ONY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ONY FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HWV:N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide'>HWV</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ony FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ony OCA], [http://pdbe.org/6ony PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ony RCSB], [http://www.ebi.ac.uk/pdbsum/6ony PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ony ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Bigelow, L]] | |||
[[Category: Longenecker, K L]] | |||
[[Category: Brd2]] | |||
[[Category: Inhibitor]] | |||
[[Category: Signaling protein]] | |||
Revision as of 15:32, 29 January 2020
BRD2_Bromodomain1 complex with inhibitor 744
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