6in1: Difference between revisions
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==Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6== | |||
<StructureSection load='6in1' size='340' side='right'caption='[[6in1]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6in1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IN1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IN1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LOC:N-[(7S)-1,2,3,10-TETRAMETHOXY-9-OXO-6,7-DIHYDRO-5H-BENZO[D]HEPTALEN-7-YL]ETHANAMIDE'>LOC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6in1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6in1 OCA], [http://pdbe.org/6in1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6in1 RCSB], [http://www.ebi.ac.uk/pdbsum/6in1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6in1 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Kitakami, R]] | |||
[[Category: Kosaka, Y]] | |||
[[Category: Matsumoto, K]] | |||
[[Category: Mizuguchi, M]] | |||
[[Category: Nabeshima, Y]] | |||
[[Category: Yokoyama, T]] | |||
[[Category: Bromodomain-containing protein 4]] | |||
[[Category: Transcription]] | |||
Revision as of 08:59, 30 October 2019
Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6
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