6rva: Difference between revisions
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==STRUCTURE OF [ASP58]-IGF-I ANALOGUE== | |||
<StructureSection load='6rva' size='340' side='right'caption='[[6rva]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rva]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVA FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rva OCA], [http://pdbe.org/6rva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rva RCSB], [http://www.ebi.ac.uk/pdbsum/6rva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rva ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[http://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Jiracek, J]] | [[Category: Jiracek, J]] | ||
[[Category: Socha, O]] | [[Category: Socha, O]] | ||
[[Category: Zakova, L]] | [[Category: Zakova, L]] | ||
[[Category: Hormone]] | |||
[[Category: Igf-i analogue]] | |||
Revision as of 10:41, 2 October 2019
STRUCTURE OF [ASP58]-IGF-I ANALOGUE
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