6rvx: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6rvx is ~~ON HOLD~~ ~~until Paper Publication~~

==Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6rvx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVX FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rvy|6rvy]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvx OCA], [http://pdbe.org/6rvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rvx RCSB], [http://www.ebi.ac.uk/pdbsum/6rvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvx ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AAAT_HUMAN AAAT_HUMAN]] Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).<ref>PMID:10708449</ref> <ref>PMID:23492904</ref> <ref>PMID:8702519</ref> (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.<ref>PMID:10051606</ref> <ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.<ref>PMID:10196349</ref> (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.<ref>PMID:10196349</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Garaeva, A A]]

[[Category: Guskov, A]]

[[Category: Paulino, C]]

[[Category: Slotboom, D J]]

[[Category: Membrane protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6rvx is ON HOLD  until Paper Publication
+==Inward-open structure of the ASCT2 (SLC1A5) mutant C467R in presence of TBOA==
+<StructureSection load='6rvx' size='340' side='right'caption='[[6rvx]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6rvx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RVX FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rvy|6rvy]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rvx OCA], [http://pdbe.org/6rvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rvx RCSB], [http://www.ebi.ac.uk/pdbsum/6rvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rvx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AAAT_HUMAN AAAT_HUMAN]] Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids (PubMed:8702519). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904).<ref>PMID:10708449</ref> <ref>PMID:23492904</ref> <ref>PMID:8702519</ref>   (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114.<ref>PMID:10051606</ref> <ref>PMID:10196349</ref>   (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus.<ref>PMID:10196349</ref>   (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.<ref>PMID:10196349</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Garaeva, A A]]
+[[Category: Guskov, A]]
+[[Category: Paulino, C]]
+[[Category: Slotboom, D J]]
+[[Category: Membrane protein]]