6a3l

Crystal structure of cytochrome c' from Shewanella violacea DSS12

spinqualitylabelsall models 6a3l, resolution 2.14Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6a3l is a 2 chain structure with sequence from Shevd. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: HEC Gene: SVI_0970 (SHEVD) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The stability of dimeric cytochrome c' from a thermophile, as compared with that of a homologous mesophilic counterpart, is attributed to strengthened interactions around the heme and at the subunit-subunit interface, both of which are molecular interior regions. Here, we showed that interactions in the equivalent interior regions of homologous cytochromes c' from two psychrophiles, Shewanella benthica and Shewanella violacea (SBCP and SVCP, respectively) were similarly weakened as compared with those of the counterparts of psychrophilic Shewanella livingstonensis and mesophilic Shewanella amazonensis (SLCP and SACP, respectively), and consistently the stability of SVCP, SLCP, and SACP increased in that order. Therefore, the stability of cytochromes c' from the psychrophile, mesophile, and thermophile is systematically regulated in their molecular interior regions. Unexpectedly, however, the stability of SBCP was significantly higher than that of SVCP, and the former had additional molecular surface interactions. Collectively, SBCP had weakened interior interactions like SVCP did, but the former was stabilized at the molecular surface as compared with the latter, implying complex multiple adaptation of the proteins because the psychrophilic sources of SBCP and SVCP are also piezophilic, thriving in deep-sea extreme environments of low temperature and high hydrostatic pressure. Stability of cytochromes c' from psychrophilic and piezophilic Shewanella species: implications for complex multiple adaptation to low temperature and high hydrostatic pressure.,Suka A, Oki H, Kato Y, Kawahara K, Ohkubo T, Maruno T, Kobayashi Y, Fujii S, Wakai S, Lisdiana L, Sambongi Y Extremophiles. 2019 Mar;23(2):239-248. doi: 10.1007/s00792-019-01077-9. Epub 2019, Jan 28. PMID:30689055 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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