4yn8

Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System

spinqualitylabelsall models 4yn8, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4yn8 is a 1 chain structure with sequence from "bacillus_diphtheriae"_kruse_in_flugge_1886 "bacillus diphtheriae" kruse in flugge 1886. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG, SO4 Gene: chrA ("Bacillus diphtheriae" Kruse in Flugge 1886) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed ChrA is a response regulator (RR) in the two-component system involved in regulating the degradation and transport of haem (Fe-porphyrin) in the pathogen Corynebacterium diphtheriae. Here, the crystal structure of full-length ChrA is described at a resolution of 1.8 A. ChrA consists of an N-terminal regulatory domain, a long linker region and a C-terminal DNA-binding domain. A structural comparison of ChrA with other RRs revealed substantial differences in the relative orientation of the two domains and the conformation of the linker region. The structural flexibility of the linker could be an important feature in rearrangement of the domain orientation to create a dimerization interface to bind DNA during haem-sensing signal transduction. Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae.,Doi A, Nakamura H, Shiro Y, Sugimoto H Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):966-71. doi:, 10.1107/S2053230X15009838. Epub 2015 Jul 29. PMID:26249683 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Response regulator 3D structure

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