Nanog: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
m oi |
||
| Line 5: | Line 5: | ||
== Structural highlights == | == Structural highlights == | ||
The struture of Nanog consists in 3 alpha helices linked to each other by loops. The so called alpha-helix1 and alpha-helix 3 play a role into binding of the protein to DNA. The alpha-helix1, localized in the N-terminal arm, binds to DNA through minor grooves, whereas alpha-helix3 binds major grooves in DNA and is considered the recognition helix, due to it´s extensive DNA contact sufarce. Alpha helices 1 and 2 are arrenged as antiparallel to each other in the terciary structure, while positioning alpha-Helix3 in a favorable way to bind to the major grooves of the DNA helical structure. | The <scene name='81/818528/Nanog/1'>struture of Nanog</scene> consists in 3 alpha helices linked to each other by loops. The so called alpha-helix1 and alpha-helix 3 play a role into binding of the protein to DNA. The alpha-helix1, localized in the N-terminal arm, binds to DNA through minor grooves, whereas alpha-helix3 binds major grooves in DNA and is considered the recognition helix, due to it´s extensive DNA contact sufarce. Alpha helices 1 and 2 are arrenged as antiparallel to each other in the terciary structure, while positioning alpha-Helix3 in a favorable way to bind to the major grooves of the DNA helical structure. | ||
== DNA binding == | == DNA binding == | ||
