3bx5: Difference between revisions

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New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_3bx5", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
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[[Image:3bx5.jpg|left|200px]]
{{Seed}}
[[Image:3bx5.png|left|200px]]


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{{STRUCTURE_3bx5|  PDB=3bx5  |  SCENE=  }}  
{{STRUCTURE_3bx5|  PDB=3bx5  |  SCENE=  }}  


'''P38 alpha map kinase complexed with BMS-640994'''
===P38 alpha map kinase complexed with BMS-640994===




==Overview==
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A novel structural class of p38alpha MAP kinase inhibitors has been identified via iterative SAR studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS-640994, a potent and selective p38alpha inhibitor that is orally efficacious in rodent models of acute and chronic inflammation.
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{{ABSTRACT_PUBMED_18313298}}


==About this Structure==
==About this Structure==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:13:14 2008''
 
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