6nne: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6nne is ~~ON HOLD~~

==Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine==

~~Authors~~: ~~Ribeiro~~, J.A., ~~Chavez~~-~~Pacheco~~, S.M., ~~Dias~~, M.V.B.

== Structural highlights ==

<table><tr><td colspan='2'>[[6nne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NNE FirstGlance].

~~Description~~: ~~Crystal structure of~~ Dihydrofolate reductase ~~from Mycobacterium tuberculosis in complex with diaverdine~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=KUP:5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine'>KUP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </td></tr>

[[Category: ~~Ribeiro~~, ~~J.A~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nne OCA], [http://pdbe.org/6nne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nne RCSB], [http://www.ebi.ac.uk/pdbsum/6nne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nne ProSAT]</td></tr>

[[Category: Dias, M.V.B]]

</table>

[[Category: ~~Chavez-Pacheco~~, ~~S.M~~]]

== Function ==

[[http://www.uniprot.org/uniprot/A5U6B6_MYCTA A5U6B6_MYCTA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]

__TOC__

</StructureSection>

[[Category: Dihydrofolate reductase]]

[[Category: Large Structures]]

[[Category: Chavez-Pacheco, S M]]

[[Category: Dias, M V.B]]

[[Category: Ribeiro, J A]]

[[Category: Antifolate]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nne is ON HOLD
+==Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine==
+<StructureSection load='6nne' size='340' side='right'caption='[[6nne]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
-Authors: Ribeiro, J.A., Chavez-Pacheco, S.M., Dias, M.V.B.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NNE FirstGlance]. <br>
-Description: Crystal structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with diaverdine
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=KUP:5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine'>KUP</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-[[Category: Ribeiro, J.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nne OCA], [http://pdbe.org/6nne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nne RCSB], [http://www.ebi.ac.uk/pdbsum/6nne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nne ProSAT]</span></td></tr>
-[[Category: Dias, M.V.B]]
+</table>
-[[Category: Chavez-Pacheco, S.M]]
+== Function ==
+[[http://www.uniprot.org/uniprot/A5U6B6_MYCTA A5U6B6_MYCTA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]
+__TOC__
+</StructureSection>
+[[Category: Dihydrofolate reductase]]
+[[Category: Large Structures]]
+[[Category: Chavez-Pacheco, S M]]
+[[Category: Dias, M V.B]]
+[[Category: Ribeiro, J A]]
+[[Category: Antifolate]]
+[[Category: Oxidoreductase]]