Eukaryotic initiation factor: Difference between revisions
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== Function == | == Function == | ||
'''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG<ref>PMID:16449648</ref>. For details | '''Eukaryotic initiation factors''' (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG<ref>PMID:16449648</ref>. | ||
*'''EIF1''' is implicated in the stringency of start codon selection<ref>PMID:28541577</ref>. <br /> | |||
*'''EIF2''' binds GTP and Met-tRNA and transfers Met-tRNA to the ribosomal 40S subunit<ref>PMID:10216940</ref>. <br /> | |||
*'''EIF3''' attaches to the 5'-terminal regions mRNA and scan along it to the initiation codon<ref>PMID:26344199</ref>. <br /> | |||
*'''EIF4''' recognizes the m7GpppN cap structure at the 5'-terminal of mRNA<ref>PMID:18443631</ref>. For details see [[C-terminal portion of human eIF4GI]].<br /> | |||
*'''EIF5''' is implicated in the stringency of start codon selection<ref>PMID:25114053</ref>. <br /> | |||
*'''EIF6''' is involved in maturation and/or export from the nucleus of the 60S ribosomal subunit<ref>PMID:16814427</ref>. <br /> | |||
== Disease == | == Disease == | ||
