Exonuclease

spinqualitylabelsall models E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion (PDB code 1fxx) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Exonucleases (ExN) cleave nucleotides at the end of a polynucleotide chain. In E. coli there are ExN I to VIII. ExN were found in human and yeast as well. ExN-I cleaves single-stranded DNA. ExN-II is associated with DNA polymerase. ExN-III cleaves double-stranded DNA. ExN-IV cleavage results in nucleoside monophosphate. ExN-V cleaves linear double-stranded DNA. ExN-VIII requires a free 5’ OH group for reacting. ExNX can degrade both single-stranded DNA and duplex DNA with 3'-5' polarity For phage ExN see Sand box 211. Mg coordination site in E. coli exonuclease I (PDB code 1fxx). Water molecules shown as red spheres. 3D Structures of exonuclease Exonuclease 3D structures

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