6s21: Difference between revisions
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==Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf)== | |||
<StructureSection load='6s21' size='340' side='right'caption='[[6s21]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s21]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S21 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene>, <scene name='pdbligand=BDP:BETA-D-GLUCOPYRANURONIC+ACID'>BDP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GCD:4,5-DEHYDRO-D-GLUCURONIC+ACID'>GCD</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s21 OCA], [http://pdbe.org/6s21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s21 RCSB], [http://www.ebi.ac.uk/pdbsum/6s21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s21 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ENDSF_BACTN ENDSF_BACTN]] Endosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS) and dermatan sulfate (DS). Efficiently hydrolyzes sulfate groups from a broad range of substrate size, including disaccharide to high molecular weight CS and DS polymers. Has a strict specificity for the 4-O-sulfate groups of galactosamine (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).<ref>PMID:25002587</ref> <ref>PMID:25002587</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Basle, A]] | |||
[[Category: Cartmell, A]] | [[Category: Cartmell, A]] | ||
[[Category: Henrissat, B]] | |||
[[Category: Ndeh, D]] | |||
[[Category: Strahl, H]] | [[Category: Strahl, H]] | ||
[[Category: Terrapon, N]] | [[Category: Terrapon, N]] | ||
[[Category: | [[Category: Cazyme]] | ||
[[Category: | [[Category: Glycobiology]] | ||
[[Category: Glycosaminoglycan]] | |||
[[Category: Gut microbiota]] | |||
[[Category: Hydrolase]] | |||
Revision as of 08:08, 5 February 2020
Metabolism of multiple glycosaminoglycans by bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (BT33494S-sulf)
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