5a60: Difference between revisions

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<StructureSection load='5a60' size='340' side='right'caption='[[5a60]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='5a60' size='340' side='right'caption='[[5a60]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a60]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A60 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a60]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A60 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PO:TRIPHOSPHATE'>3PO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PO:TRIPHOSPHATE'>3PO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a5y|5a5y]], [[5a61|5a61]], [[5a64|5a64]], [[5a65|5a65]], [[5a66|5a66]], [[5a67|5a67]], [[5a68|5a68]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a60 OCA], [https://pdbe.org/5a60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a60 RCSB], [https://www.ebi.ac.uk/pdbsum/5a60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a60 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triphosphatase Triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.25 3.6.1.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a60 OCA], [http://pdbe.org/5a60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a60 RCSB], [http://www.ebi.ac.uk/pdbsum/5a60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a60 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/3PASE_ECOLI 3PASE_ECOLI] Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside-linked). Catalyzes the hydrolysis of inorganic triphosphate (PPPi), which could be cytotoxic because of its high affinity for calcium ion, thereby interfering with calcium signaling. It also hydrolyzes slowly thiamine triphosphate (ThTP). YgiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in E.coli, where the main enzyme responsible for hydrolysis of PPPi is inorganic pyrophosphatase (PPase).<ref>PMID:22984449</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Triphosphatase]]
[[Category: Hothorn M]]
[[Category: Hothorn, M]]
[[Category: Martinez J]]
[[Category: Martinez, J]]
[[Category: Truffault V]]
[[Category: Truffault, V]]
[[Category: Hydrolase]]
[[Category: Inorganic polyphosphate]]
[[Category: Triphosphate tunnel metalloenzyme]]
[[Category: Tripolyphosphate]]
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