4zrl: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4zrl' size='340' side='right'caption='[[4zrl]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='4zrl' size='340' side='right'caption='[[4zrl]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zrl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zrl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zrl OCA], [https://pdbe.org/4zrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zrl RCSB], [https://www.ebi.ac.uk/pdbsum/4zrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zrl ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gld-2, ZC308.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), gld-3, T07F8.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zrl OCA], [http://pdbe.org/4zrl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zrl RCSB], [http://www.ebi.ac.uk/pdbsum/4zrl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zrl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GLD2_CAEEL GLD2_CAEEL]] Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline.<ref>PMID:12239571</ref> <ref>PMID:14660440</ref> <ref>PMID:15063172</ref> <ref>PMID:15514056</ref> <ref>PMID:15911573</ref> <ref>PMID:17012378</ref> <ref>PMID:9550713</ref> [[http://www.uniprot.org/uniprot/GLD3_CAEEL GLD3_CAEEL]] Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continued production of sperm and inhibition of oogenesis. Together with gld-2, promotes the transition from mitosis to meiosis.<ref>PMID:12431376</ref> <ref>PMID:15454534</ref> <ref>PMID:19461891</ref> 
[https://www.uniprot.org/uniprot/GLD2_CAEEL GLD2_CAEEL] Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline.<ref>PMID:12239571</ref> <ref>PMID:14660440</ref> <ref>PMID:15063172</ref> <ref>PMID:15514056</ref> <ref>PMID:15911573</ref> <ref>PMID:17012378</ref> <ref>PMID:9550713</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 21:
==See Also==
==See Also==
*[[Poly(A) RNA polymerase|Poly(A) RNA polymerase]]
*[[Poly(A) RNA polymerase|Poly(A) RNA polymerase]]
*[[RNA polymerase|RNA polymerase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caenorhabditis elegans]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Polynucleotide adenylyltransferase]]
[[Category: Bonneau F]]
[[Category: Bonneau, F]]
[[Category: Conti E]]
[[Category: Conti, E]]
[[Category: Eckmann CR]]
[[Category: Eckmann, C R]]
[[Category: Nakel K]]
[[Category: Nakel, K]]
[[Category: Polyadenylation]]
[[Category: Post-transcriptional regulation]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4zrl"