4zp3: Difference between revisions

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<StructureSection load='4zp3' size='340' side='right'caption='[[4zp3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
<StructureSection load='4zp3' size='340' side='right'caption='[[4zp3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zp3]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZP3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZP3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zp3]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZP3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRKAR2A, PKR2, PRKAR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), AKAP7, AKAP15, AKAP18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zp3 OCA], [https://pdbe.org/4zp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zp3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zp3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zp3 OCA], [http://pdbe.org/4zp3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zp3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zp3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zp3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAP2_HUMAN KAP2_HUMAN]] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. [[http://www.uniprot.org/uniprot/AKA7A_HUMAN AKA7A_HUMAN]] Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref> <ref>PMID:9545239</ref> 
[https://www.uniprot.org/uniprot/AKA7G_HUMAN AKA7G_HUMAN] Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.<ref>PMID:10613906</ref> <ref>PMID:17244820</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Autenrieth, K]]
[[Category: Autenrieth K]]
[[Category: Daumke, O]]
[[Category: Daumke O]]
[[Category: Faelber, K]]
[[Category: Faelber K]]
[[Category: Goetz, F]]
[[Category: Goetz F]]
[[Category: Heinemann, U]]
[[Category: Heinemann U]]
[[Category: Herberg, F W]]
[[Category: Herberg FW]]
[[Category: Klussmann, E]]
[[Category: Klussmann E]]
[[Category: Krause, G]]
[[Category: Krause G]]
[[Category: Kreuchwig, A]]
[[Category: Kreuchwig A]]
[[Category: Roske, Y]]
[[Category: Roske Y]]
[[Category: Zuehlke, K]]
[[Category: Zuehlke K]]
[[Category: Akap]]
[[Category: Amphiphathic helix]]
[[Category: Anchor point]]
[[Category: Dd-domain]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/4zp3"