Kdo-8-phosphate synthase

spinqualitylabelsall models Metallo Kdo-8-phosphate synthase tetramer complex with phosphoenolpyruvate, glycerol, Cl- (green), Na+ (large purple) and Mn+2 (small purple) ion, 3fyp Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Kdo-8-phosphate synthase or 2-dehydro-3-deoxyphosphooctonate aldolase (KPS) catalyzes the formation of the phosphorylated rare sugar Kdo-8-phosphate (Kdo-8-P) from phosphoenolpyruvate (PEP) and D-arabinose-5-phosphate (A5P). Some bacteria like Aquifex aeolicus have Metallo KPS which is a metal-requiring enzyme while others like E.coli have a Non-metallo KPS which does not require a divalent cation for its activity. Kdo-8-P is found in cell walls of higher plants and some green algae. Structural highlights The biological assembly of Metallo Kdo-8-phosphate synthase from Neisseria meningitidis is homotetramer. The active site of the metallo KPS contains a divalent cation and the PEP substrate. Water molecules shown as red spheres.

3D structures of Kdo-8-phosphate synthase

Updated on 11-October-2021

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• Metallo Kdo8P
  • 1fxp - AaKPS + Cd – Aquifex aeolicus
    
  • 1lrn, 1t99 - AaKPS (mutant) + Cd
    
  • 1fx6 - AaKPS
    
  • 2nws, 2nx3 - AaKPS (mutant)
    
  • 2qkf – NmKPS + Na – Neisseria meningitides
    
  • 3fyo - NmKPS (mutant) + Mn
    
  • 3qpy, 3qpz, 3qq0, 3stc, 3ste, 3stf, 4jte, 4jtf, 4jtg, 4jth, 4jti, 4jtj, 4jtk, 4jtl - NmKPS (mutant) + Na
    
  • 3qq1, 3stg - NmKPS (mutant)
    
  • 3sz8 – BpKPS-2 – Burkholderia pseudomallei
    
  • 4lu0 – KPS – Pseudomonas aeruginosa
    
  • 4z1a – HpKPS – Helicobacter pylori
    
  • 4z1b - HpKPS (mutant)
    
  • 4z1c - HpKPS + Cd
    
  • 6bng – KPS – Acinetobacter baumannii
    
• Metallo Kdo8P binary complex
  • 1fws – AaKPS + PEP + Cd
    
  • 3e0i - AaKPS + PEP + Cu
    
  • 1lro, 1t96 - AaKPS (mutant) + PEP + Cd
    
  • 1pck - AaKPS + PEP derivative + Cd
    
  • 1pe1 - AaKPS + phosphoglyceric acid + Cd
    
  • 2a21 - AaKPS + PEP + Zn
    
  • 1jcx, 1pcw - AaKPS + inhibitor + Cd
    
  • 1fy6 - AaKPS + A5P + Cd
    
  • 3e12 - AaKPS + Kdo-8-P + Cu
    
  • 2nxi, 1fwn - AaKPS + PEP
    
  • 2nwr, 2nxh - AaKPS (mutant) + PEP
    
  • 4z1d - HpKPS + PEP + Zn
    
  • 3fyp - NmKPS (mutant) + PEP + Mn
    
  • 3tmq - BpKPS + arabinose-5-phosphate
    
• Metallo Kdo8P ternary complex
  • 1fwt - AaKPS + erythrose-4-phosphate + PEP + Cd
    
  • 1jcy - AaKPS + ribose-5-phosphate + PEP + Cd
    
  • 1zha - AaKPS (mutant) + ribose-5-phosphate + PEP + Cd
    
  • 1zji - AaKPS (mutant) + ribose-5-phosphate + phosphoglyceric acid + Cd
    
  • 1fww - AaKPS + A5P + PEP + Cd
    
  • 2a2i - AaKPS + A5P + PEP + Zn
    
  • 1lrq, 1t8x - AaKPS (mutant) + A5P + PEP + Cd
    
  • 1fxq - AaKPS + A5P + PEP
    
  • 2nx1, 2ef9 - AaKPS (mutant) + A5P + PEP
    
  • 2nxg - AaKPS (mutant) + octanoic acid derivative + A5P + PEP
    
  • 3und - BpKPS + arabinose-5-phosphate + PEP
    
• Non-metallo Kdo8P
  • 1d9e, 1gg0, 1x8f – EcKPS - Escherichia coli
    
  • 1o60 - KPS – Haemophilus influenza
    
  • 3e9a - KPS – Vibrio cholerae
    
  • 3fs2 - KPS – Brucella melitensis
    
  • 3t4c, 3tml - KPS – Burkholderia ambifaria
• Non-metallo Kdo8P binary complex
  • 1g7u, 1q3n - EcKPS + PEP
    
  • 1phq, 1pl9 - EcKPS + PEP derivative
    
  • 1phw - EcKPS + A5P derivative
    
  • 1g7v - EcKPS + inhibitor
    
  • 1x6u - EcKPS + Kdo-8-P

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