6pik: Difference between revisions
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The | ==Tetrameric cryo-EM ArnA== | ||
<StructureSection load='6pik' size='340' side='right'caption='[[6pik]], [[Resolution|resolution]] 7.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6pik]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PIK FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pik OCA], [http://pdbe.org/6pik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pik RCSB], [http://www.ebi.ac.uk/pdbsum/6pik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pik ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/A0A3W2RQG2_ECOLX A0A3W2RQG2_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS01095241] [[http://www.uniprot.org/uniprot/A0A479JW67_ECOLX A0A479JW67_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS01095241] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Gehring, K]] | |||
[[Category: Yang, M]] | |||
[[Category: Antibiotic]] | |||
[[Category: Hexamer]] | |||
[[Category: Polymyxin resistance]] | |||
[[Category: Tetramer]] | |||
