6s0i: Difference between revisions
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==Crystal structure of Escherichia coli Glyoxalase II with L-Tartrate in the active site== | |||
<StructureSection load='6s0i' size='340' side='right'caption='[[6s0i]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6s0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S0I FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.803Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s0i OCA], [https://pdbe.org/6s0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s0i RCSB], [https://www.ebi.ac.uk/pdbsum/6s0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s0i ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLO2_ECOLI GLO2_ECOLI] Type II glyoxalase that catalyzes the hydrolysis of (R)-S-lactoylglutathione to (R)-lactate and glutathione (PubMed:25670698, PubMed:17196158). Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli (PubMed:25670698). The two isoenzymes have additive effects and ensure maximal MG degradation (PubMed:25670698).<ref>PMID:17196158</ref> <ref>PMID:25670698</ref> | |||
==See Also== | |||
*[[Glyoxalase 3D structures|Glyoxalase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: McDonough MA]] | |||
[[Category: Schofield CJ]] | |||
[[Category: Skorupskaite A]] | |||
Latest revision as of 12:32, 24 January 2024
Crystal structure of Escherichia coli Glyoxalase II with L-Tartrate in the active site
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