6bjg: Difference between revisions

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<StructureSection load='6bjg' size='340' side='right'caption='[[6bjg]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='6bjg' size='340' side='right'caption='[[6bjg]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6bjg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cirv Cirv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BJG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BJG FirstGlance]. <br>
<table><tr><td colspan='2'>[[6bjg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Carnation_Italian_ringspot_virus Carnation Italian ringspot virus] and [https://en.wikipedia.org/wiki/Lampyridae Lampyridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BJG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BJG FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39443 CIRV])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bjg OCA], [http://pdbe.org/6bjg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bjg RCSB], [http://www.ebi.ac.uk/pdbsum/6bjg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bjg ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bjg OCA], [https://pdbe.org/6bjg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bjg RCSB], [https://www.ebi.ac.uk/pdbsum/6bjg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bjg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P19_CIRV P19_CIRV]] Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA.<ref>PMID:14697199</ref> <ref>PMID:19254536</ref>
[https://www.uniprot.org/uniprot/P19_CIRV P19_CIRV] Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA.<ref>PMID:14697199</ref> <ref>PMID:19254536</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6bjg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6bjg" style="background-color:#fffaf0;"></div>
==See Also==
*[[P19|P19]]
*[[RNA silencing suppressor|RNA silencing suppressor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cirv]]
[[Category: Carnation Italian ringspot virus]]
[[Category: Lampyridae]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Foss, D V]]
[[Category: Foss DV]]
[[Category: Macrae, I J]]
[[Category: Macrae IJ]]
[[Category: Pezacki, J P]]
[[Category: Pezacki JP]]
[[Category: Schirle, N]]
[[Category: Schirle N]]
[[Category: Altered affinity for microrna]]
[[Category: Rna binding protein]]
[[Category: Rna silencing sirna binding protein p19]]
[[Category: Viral suppressor]]

Latest revision as of 14:43, 4 October 2023

CIRV p19 mutant T111H in complex with siRNA

6bjg, resolution 2.29Å

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